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- 题名/责任者:
- Immunotoxicology strategies for pharmaceutical safety assessment / edited by Danuta J. Herzyk and Jeanine L. Bussiere.
- 出版发行项:
- Hoboken, N.J. : Wiley, c2008.
- ISBN:
- 9780470122389 (cloth)
- 载体形态项:
- xxviii, 402 p., [12] p. of plates : ill. (some col.) ; 25 cm.
- 附加个人名称:
- Herzyk, Danuta J.
- 附加个人名称:
- Bussiere, Jeanine L.
- 论题主题:
- Immunotoxicology.
- 论题主题:
- Immune system-Effect of drugs on.
- 论题主题:
- Toxicity testing.
- 论题主题:
- Drugs-Toxicology.
- 中图法分类号:
- R967
- 中图法分类号:
- R99
- 书目附注:
- Includes bibliographical references and index.
- 内容附注:
- Current regulatory expectations for immunotoxicologyy evaluation of pharmaceuticals / Kenneth L. Hastings -- Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans -- Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley --
- 内容附注:
- Need for specialized immunotoxicity tests / Kazuichi Nakamura -- Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj -- T cell-dependent antibody response tests / Joseph R. Piccotti -- Natural killer cell assay and other innate immunity tests / Lisa Plitnick -- Cellular immune response in delayed-type hypersensitivity test / Karen Price -- Evaluation of drug effects on immune cell phenotypes / Laurie Iciek --
- 内容附注:
- Functional cellular responses and cytokine profiles / Elizabeth R. Gore -- Application of flow cytometry in drug development / Padma Narayanan ... [et al.] -- Animal models of host resistance / Gary R. Burleson and Florence G. Burleson -- Approaches to evaluation of autoimmunity / Danuta J. Herzyk --
- 内容附注:
- Differentiating between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho -- Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere -- Antidrug antibody responses in nonclinical studies and their implications / Barbara Mounho -- Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House --
- 内容附注:
- Immunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski ... [et al.] -- Systemic hypersensitivity / Raymond Pieters -- Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier -- Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas -- Developmental immunotoxicity in nonhuman primates / Pauline L. Martin and Eberhard Buse --
- 内容附注:
- Alternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski -- Animal models for preclinical comparative immunogenicity testing / Daniel Wierda -- T cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer -- Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes.
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