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• 001 0000446587

• 003 SCNU

• 005 20130110152700.0

• 008 120911r20122010cc a b 001 0 eng d

• 020 __ |a 9787030344397

• 040 __ |a PUL |c PUL

• 041 0_ |a eng |b chi |f chi

• 050 _4 |a QH450.25 |b .R63

• 093 __ |a Q522 |2 5

• 099 __ |a CAL 022012096460

• 245 00 |a RNA interference : |b from biology to clinical applications = RNA干扰 : 从生物学到临床应用 / |c edited by Wei-Ping Min, Thomas Ichim.

• 246 31 |a RNA干扰 : |b 从生物学到临床应用

• 260 __ |a 北京 : |b 科学出版社, |c 2012.

• 300 __ |a xvi, 450 p. : |b ill. ; |c 27 cm.

• 490 0_ |a 实验室解决方案

• 500 __ |a “科爱传播.导读版”--Cover.

• 504 __ |a Includes bibliographical references and index.

• 505 0_ |a Endogenous antiviral mechanisms of RNA interference : a comparative biology perspective / Abubaker M.E. Sidahmed and Bruce Wilkie -- Monitoring innate immune recruitment by siRNAs in mammalian cells / Michael P. Gantier and Bryan R.G. Williams -- Current knowledge of microRNAs and noncoding RNAs in virus-infected cells / Dominique L. Ouellet and Patrick Provost -- Allele-specific silencing by RNA interference / Hirohiko Hohjoh -- Computational siRNA design considering alternative splicing / Young J. Kim -- Bioinformatic approaches to siRNA selection and optimization / Pirkko Muhonen and Harry Holthofer -- Optimized gene silencing by co-expression of mulitple shRNAs in a single vector / Yasuhito Ishigaki, Akihiro Nagao, and Tsukasa Matsunaga -- Strategies in designing multigene expression units to downregulate HIV-1 / Jane Zhang and John J. Rossi -- Designing optimal siRNA based on target site accessibility / Ivo L. Hofacker and Hakim Tafer -- Chemical synthesis of 2'-O-alkylated siRNAs / Joachim W. Engels ... [et al.] -- siRNA specific delivery system for targeting dendritic cells / Xiufen Zheng ... [et al.] -- Hydrodynamic delivery protocols / Piotr G. Rychahou and B. Mark Evers -- New methods for reverse transfection with siRNA from a solid surface / Satoshi Fujita ... [et al.] -- Nonviral siRNA delivery for gene silencing in neurodegenerative diseases / Satya Prakash, Meenakshi Malhotra, and Venkatesh Rengaswamy --

• 505 8_ |a Using siRNA to uncover novel oncogenic signaling pathways / Jin-Mei Lai, Chi-Ying F. Huang, and Chang-Han Chen -- Biodegradable polymer-mediated sh/siRNA delivery for cancer studies / Dhananjay J. Jere and Chong-Su Cho -- Cellular siRNA delivery using TatU1A and photo-induced RNA interference / Tamaki Endoh and Takashi Ohtsuki -- Polyethylenimine (PEI)/siRNA-mediated gene knockdown in vitro and in vivo / Sabrina H?bel and Achim Aigner -- Transfection of siRNAs in multiple myeloma cell lines / Jose L.R. Brito, Nicola Brown, and Garth J. Morgan -- A new approach for therapeutic use by RNA interference in the brain / Yukio Akaneya -- Inhibitory RNA molecules in immunotherapy for cancer / Chih-Ping Mao and T.-C. Wu -- Preventing tissue injury using siRNA / Zhu-Xu Zhang ... [et al.] -- Preventing immune rejection through gene silencing / Xusheng Zhang, Mu Li, and Wei-Ping Min -- Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease / Miyuki Azuma, Patcharee Ritprajak, and Masaaki Hashiguchi -- Direct application of siRNA for in vivo pain research / Philippe Sarret, Louis Doré-Savard, and Nicolas Beaudet -- A potential therapeutic for pandemic influenza using RNA interference / Shaguna Seth ... [et al.] -- Evaluation of targets for ovarian cancer gene silencing therapy : in vitro and in vivo approaches / Anastasia Malek and Oleg Tchernitsa.

• 534 __ |p Reprint. Originally published: |c New York : Humana Press, c2010. |z 9781607615873 (alk. paper)

• 650 _0 |a RNA editing.

• 650 _0 |a Gene silencing.

• 650 12 |a RNA Interference |v Laboratory Manuals.

• 650 22 |a Gene Silencing |v Laboratory Manuals.

• 700 1_ |a Min, Wei-Ping.

• 700 1_ |a Ichim, Thomas, |d 1976-

• 830 _0 |a Methods in molecular biology (Clifton, N.J.) ; |v v. 623.

• 830 _0 |a Springer protocols.

• 920 __ |a 242430 |z 2

• 950 __ |a SCNU |f Q522/M663