机读格式显示(MARC)
- 000 03390cam a2200397 a 4500
- 008 080402s2008 njuaf b 001 0 eng
- 020 __ |a 9780470122389 (cloth)
- 040 __ |a DNLM/DLC |c DLC |d BTCTA |d BAKER |d NLM |d YDXCP |d C#P
- 050 00 |a RC582.17 |b .I47 2008
- 082 00 |a 616.97/071 |2 22
- 099 __ |a CAL 022008147463
- 245 00 |a Immunotoxicology strategies for pharmaceutical safety assessment / |c edited by Danuta J. Herzyk and Jeanine L. Bussiere.
- 260 __ |a Hoboken, N.J. : |b Wiley, |c c2008.
- 300 __ |a xxviii, 402 p., [12] p. of plates : |b ill. (some col.) ; |c 25 cm.
- 504 __ |a Includes bibliographical references and index.
- 505 0_ |a Current regulatory expectations for immunotoxicologyy evaluation of pharmaceuticals / Kenneth L. Hastings -- Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans -- Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley --
- 505 0_ |a Need for specialized immunotoxicity tests / Kazuichi Nakamura -- Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj -- T cell-dependent antibody response tests / Joseph R. Piccotti -- Natural killer cell assay and other innate immunity tests / Lisa Plitnick -- Cellular immune response in delayed-type hypersensitivity test / Karen Price -- Evaluation of drug effects on immune cell phenotypes / Laurie Iciek --
- 505 0_ |a Functional cellular responses and cytokine profiles / Elizabeth R. Gore -- Application of flow cytometry in drug development / Padma Narayanan ... [et al.] -- Animal models of host resistance / Gary R. Burleson and Florence G. Burleson -- Approaches to evaluation of autoimmunity / Danuta J. Herzyk --
- 505 0_ |a Differentiating between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho -- Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere -- Antidrug antibody responses in nonclinical studies and their implications / Barbara Mounho -- Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House --
- 505 0_ |a Immunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski ... [et al.] -- Systemic hypersensitivity / Raymond Pieters -- Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier -- Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas -- Developmental immunotoxicity in nonhuman primates / Pauline L. Martin and Eberhard Buse --
- 505 0_ |a Alternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski -- Animal models for preclinical comparative immunogenicity testing / Daniel Wierda -- T cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer -- Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes.
- 650 _0 |a Immunotoxicology.
- 650 _0 |a Immune system |x Effect of drugs on.
- 650 _0 |a Toxicity testing.
- 650 _0 |a Drugs |x Toxicology.
- 700 1_ |a Herzyk, Danuta J.
- 700 1_ |a Bussiere, Jeanine L.
- 950 __ |a SCNU |f R967/H582