机读格式显示(MARC)
- 000 02306cam 22004094a 4500
- 008 071101s2007 enka b 001 0 eng
- 020 __ |a 9780470018774 (cloth : alk. paper)
- 020 __ |a 0470018771 (cloth : alk. paper)
- 035 __ |a (OCoLC)ocn180907943
- 035 __ |a (OCoLC)180907943
- 040 __ |a DNLM/DLC |c DLC |d NLM |d BAKER |d YDXCP |d BWKUK |d DLC
- 050 00 |a RM301.25 |b .S46 2007
- 082 00 |a 615/.190727 |2 22
- 245 10 |a Statistical issues in drug development / |c Stephen Senn.
- 260 __ |a Chichester, England ; |a Hoboken, NJ : |b John Wiley & Sons, |c c2007.
- 300 __ |a xix, 498 p. : |b ill. ; |c 25 cm.
- 440 _0 |a Statistics in practice
- 504 __ |a Includes bibliographical references and index.
- 505 0_ |a A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information --
- 505 0_ |a The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies --
- 505 0_ |a Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters.
- 650 _0 |a Drug development |x Statistical methods.
- 650 12 |a Clinical Trials as Topic.
- 650 22 |a Statistics as Topic |x methods.
- 950 __ |a SCNU |f R965/S478-2
- 999 __ |M zxq |m 20080521 16:10:08 |G zxq |g 20080521 16:10:51
- 907 __ |a SCNU |f R965/S478-2